N-methylpiperazine

CAS:109-01-3

MF:C5H12N2

MW:100.16

EINECS:203-639-5

MDL No.:MFCD00005966

 

Synonyms

1-Methylpiperazine

4-Methylpiperazine

PIPERAZINE, 1-METHYL-

n-methyl piperazine

Piperazine, methyl-

METHYLPIPERAZINE

methyl piperazine

N-METHYL-PIPERAZINE

 

Properties	N-methylpiperazine
Chemical formula	C5H12N2
Molar mass	100.165 g·mol−1
Melting point	−6 °C (21 °F; 267 K)
Boiling point	138 °C (280 °F; 411 K)
Density	0.903 g/mL at 25 °C(lit.)
Vapor density	3.5 (vs air)
Vapor pressure	12 hPa (20 °C)
Refractive index	n20/D 1.466(lit.)
Flash point:	108 °F
Storage temp.	2-8°C
Solubility	Chloroform (Soluble), Methanol (Soluble)
Pka	pK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1)
Form	Liquid
Color	Clear
Specific Gravity	0.903
PH	11-12 (50g/l, H2O, 20℃)
Explosive limit	1.2-9.9%(V)
Water Solubility	soluble
Sensitive	Hygroscopic

 

 

Methylpiperazine is a common building block used in organic synthesis. For example, N-methylpiperazine is used in the manufacture of various pharmaceutical drugs including cyclizine, meclizine, and sildenafil.

The lithium salt, lithium N-methylpiperazide, is used as a reagent in organic synthesis for protection of aryl aldehydes.

Synthesis

Industrially, N-methylpiperazine is produced by reacting diethanolamine and methylamine at 250 bar and 200 °C.

Piperazine Morpholine Piperidine AmideEthyl IC50

1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone.

It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene.

· It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin,rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone.

· Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres.

· In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative

Piperidines,Piperidones,Piperazines;Piperaizine;Piperazinederivates;Piperazines;Nitrogencontaining;AlphaSort;Heterocyclics;BuildingBlocks;HeterocyclicBuildingBlocks;BuildingBlocks;C4toC8;ChemicalSynthesis;HeterocyclicBuildingBlocks;Benzotriazoles,Triazoles;

 

 

Transition metal halides such as chromium chloride, manganese chloride and potassium chloride, sodium chloride and other halides have a certain solubility in DMSO, so they can be used in organic electrochemistry.

Dimethyl sulfoxide is widely used as a solvent and reaction reagent, especially as a processing solvent and drawing solvent in acrylonitrile polymerization, as a solvent for polyurethane synthesis and drawing, as a solvent for polyamide, polyimide and polysulfone resin synthesis, as well as a solvent for aromatics, butadiene extraction and synthesis of chlorofluoroaniline.

DMSO is dimethyl sulfoxide and has a wide range of uses. Used as a solvent for acetylene, aromatics, sulfur dioxide and other gases and as a spinning solvent for acrylic fibers. It is a very important aprotic polar solvent soluble in both water and organic solvents. It is highly permeable to the skin and helps the drug penetrate into the human body. It can also be used as an additive to pesticides. It's also a very important chemical agent.

DMSO is also a osmotic protective agent, which can reduce the freezing point of cells, reduce the formation of ice crystals, reduce the damage of free radicals to cells, and change the permeability of biofilms to electrolytes, drugs, poisons and metabolites.

 

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